Blood components are essential to regulate microcirculatory blood flow

Blood components are essential to regulate microcirculatory blood flow

We read with interest the article by Jacob and colleagues [1] on the regulation of microcirculatory blood flow. In our opinion, the authors missed an important parameter, i.e., blood components and, particularly, red blood cells (RBC). This is regrettable since blood composition is the main parameter that we can influence by our therapies (fluid resuscitation, blood or albumin transfusion) in s...

Biphasic Blood Flow in Mesentery Microcirculatory Networks

The purpose of this paper is to investigate how changes in the plasma skimming coefficient affect the hemoconcentration within blood vessel networks. Due to the differences in plasma and red blood cells (RBCs) phases, the RBCs tend to flow at a different rate causing a difference in hematocrit concentration at a bifurcation in a network. This can be quite important when looking into how efficie...

Estimation of Microcirculatory Blood Flow Velocity Profiles

An approach to estimate blood flow cross-sectional velocity profiles in intravital microscopy videos of post-capillary venules is proposed. Given an image sequence, the cross-section upon which the velocity profile is to be estimated is manually chosen. The velocity of each streamline, assumed perpendicular to the chosen cross-section, is estimated separately from other streamlines, except for ...

Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study

INTRODUCTION Our goal was to assess the effects of titration of a norepinephrine infusion to increasing levels of mean arterial pressure (MAP) on sublingual microcirculation. METHODS Twenty septic shock patients were prospectively studied in two teaching intensive care units. The patients were mechanically ventilated and required norepinephrine to maintain a mean arterial pressure (MAP) of 65...

Response to "do vasomotor nerves significantly regulate cerebral blood flow?".